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cell lines app transfected sh sy5y neuroblastoma cells human  (ATCC)
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ATCC cell lines app transfected sh sy5y neuroblastoma cells human
Cell Lines App Transfected Sh Sy5y Neuroblastoma Cells Human, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cdna  (New England Biolabs)
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app protein  (MedChemExpress)
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MedChemExpress app protein
Disordered cellular communication in TSCST. ( A ) Bar plot showing the number of inferred interactions in the leading edge and the tumor core. ( B ) Bar plot showing the interaction strength in the leading edge and the tumor core. ( C ) Circle plots display ligand-receptor interaction weights between distinct cellular components in the leading edge and the tumor core. Colors distinguish cell types. The circle size is proportional to the number of cells in each cluster, and the edge width represents communication probability. ( D ) Dot plots show the increased ligand-receptor interactions on the leading edge. ( E ) Dot plots showing the increased ligand-receptor interactions in the tumor core. ( F ) Dot plots show increased signaling <t>in</t> <t>macrophages</t> to tumor and Sertoli cells. ( G ) Feature plots of <t>APP-CD74</t> by ST in Patient 3 and Patient 4. ( H ) Feature plots of MDK-NCL by ST in Patient 3 and Patient 4. ( I ) Mapped SPP and MK signaling pathways in ST, colored by Seurat clusters. ( J ) Violin plots showing the expression level of APP-CD74 genes across the cell types in the leading edge and the tumor core, respectively. The y-axis shows the normalized read count. ( K ) Representative immunofluorescence images showing expression of CTNNB1 and CD74 (n = 4). Nuclei were stained with DAPI. ( L ) Relative mRNA expression of MRC1 and ARG1 (M2-type macrophage markers) and IL1B (M1-type macrophage marker) in macrophages treated with APP. ( M ) Relative mRNA expression of MMP2 (a marker associated with phagocytic function in macrophages) in macrophages treated with APP. The P value was calculated by Welch’s t-test. *P < 0.05, **P < 0.01, ***P < 0.001
App Protein, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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app d high throughput sequencing primer kit  (Complete Genomics Inc)
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Complete Genomics Inc app d high throughput sequencing primer kit
Disordered cellular communication in TSCST. ( A ) Bar plot showing the number of inferred interactions in the leading edge and the tumor core. ( B ) Bar plot showing the interaction strength in the leading edge and the tumor core. ( C ) Circle plots display ligand-receptor interaction weights between distinct cellular components in the leading edge and the tumor core. Colors distinguish cell types. The circle size is proportional to the number of cells in each cluster, and the edge width represents communication probability. ( D ) Dot plots show the increased ligand-receptor interactions on the leading edge. ( E ) Dot plots showing the increased ligand-receptor interactions in the tumor core. ( F ) Dot plots show increased signaling <t>in</t> <t>macrophages</t> to tumor and Sertoli cells. ( G ) Feature plots of <t>APP-CD74</t> by ST in Patient 3 and Patient 4. ( H ) Feature plots of MDK-NCL by ST in Patient 3 and Patient 4. ( I ) Mapped SPP and MK signaling pathways in ST, colored by Seurat clusters. ( J ) Violin plots showing the expression level of APP-CD74 genes across the cell types in the leading edge and the tumor core, respectively. The y-axis shows the normalized read count. ( K ) Representative immunofluorescence images showing expression of CTNNB1 and CD74 (n = 4). Nuclei were stained with DAPI. ( L ) Relative mRNA expression of MRC1 and ARG1 (M2-type macrophage markers) and IL1B (M1-type macrophage marker) in macrophages treated with APP. ( M ) Relative mRNA expression of MMP2 (a marker associated with phagocytic function in macrophages) in macrophages treated with APP. The P value was calculated by Welch’s t-test. *P < 0.05, **P < 0.01, ***P < 0.001
App D High Throughput Sequencing Primer Kit, supplied by Complete Genomics Inc, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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gene exp app mm01344172 m1  (Thermo Fisher)
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Thermo Fisher gene exp app mm01344172 m1
Disordered cellular communication in TSCST. ( A ) Bar plot showing the number of inferred interactions in the leading edge and the tumor core. ( B ) Bar plot showing the interaction strength in the leading edge and the tumor core. ( C ) Circle plots display ligand-receptor interaction weights between distinct cellular components in the leading edge and the tumor core. Colors distinguish cell types. The circle size is proportional to the number of cells in each cluster, and the edge width represents communication probability. ( D ) Dot plots show the increased ligand-receptor interactions on the leading edge. ( E ) Dot plots showing the increased ligand-receptor interactions in the tumor core. ( F ) Dot plots show increased signaling <t>in</t> <t>macrophages</t> to tumor and Sertoli cells. ( G ) Feature plots of <t>APP-CD74</t> by ST in Patient 3 and Patient 4. ( H ) Feature plots of MDK-NCL by ST in Patient 3 and Patient 4. ( I ) Mapped SPP and MK signaling pathways in ST, colored by Seurat clusters. ( J ) Violin plots showing the expression level of APP-CD74 genes across the cell types in the leading edge and the tumor core, respectively. The y-axis shows the normalized read count. ( K ) Representative immunofluorescence images showing expression of CTNNB1 and CD74 (n = 4). Nuclei were stained with DAPI. ( L ) Relative mRNA expression of MRC1 and ARG1 (M2-type macrophage markers) and IL1B (M1-type macrophage marker) in macrophages treated with APP. ( M ) Relative mRNA expression of MMP2 (a marker associated with phagocytic function in macrophages) in macrophages treated with APP. The P value was calculated by Welch’s t-test. *P < 0.05, **P < 0.01, ***P < 0.001
Gene Exp App Mm01344172 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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app duplication  (WiCell Research Institute Inc)
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Disordered cellular communication in TSCST. ( A ) Bar plot showing the number of inferred interactions in the leading edge and the tumor core. ( B ) Bar plot showing the interaction strength in the leading edge and the tumor core. ( C ) Circle plots display ligand-receptor interaction weights between distinct cellular components in the leading edge and the tumor core. Colors distinguish cell types. The circle size is proportional to the number of cells in each cluster, and the edge width represents communication probability. ( D ) Dot plots show the increased ligand-receptor interactions on the leading edge. ( E ) Dot plots showing the increased ligand-receptor interactions in the tumor core. ( F ) Dot plots show increased signaling <t>in</t> <t>macrophages</t> to tumor and Sertoli cells. ( G ) Feature plots of <t>APP-CD74</t> by ST in Patient 3 and Patient 4. ( H ) Feature plots of MDK-NCL by ST in Patient 3 and Patient 4. ( I ) Mapped SPP and MK signaling pathways in ST, colored by Seurat clusters. ( J ) Violin plots showing the expression level of APP-CD74 genes across the cell types in the leading edge and the tumor core, respectively. The y-axis shows the normalized read count. ( K ) Representative immunofluorescence images showing expression of CTNNB1 and CD74 (n = 4). Nuclei were stained with DAPI. ( L ) Relative mRNA expression of MRC1 and ARG1 (M2-type macrophage markers) and IL1B (M1-type macrophage marker) in macrophages treated with APP. ( M ) Relative mRNA expression of MMP2 (a marker associated with phagocytic function in macrophages) in macrophages treated with APP. The P value was calculated by Welch’s t-test. *P < 0.05, **P < 0.01, ***P < 0.001
App Duplication, supplied by WiCell Research Institute Inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rabbit monoclonal anti aβ 6e10 antibody  (Novus Biologicals)
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Novus Biologicals rabbit monoclonal anti aβ 6e10 antibody
Disordered cellular communication in TSCST. ( A ) Bar plot showing the number of inferred interactions in the leading edge and the tumor core. ( B ) Bar plot showing the interaction strength in the leading edge and the tumor core. ( C ) Circle plots display ligand-receptor interaction weights between distinct cellular components in the leading edge and the tumor core. Colors distinguish cell types. The circle size is proportional to the number of cells in each cluster, and the edge width represents communication probability. ( D ) Dot plots show the increased ligand-receptor interactions on the leading edge. ( E ) Dot plots showing the increased ligand-receptor interactions in the tumor core. ( F ) Dot plots show increased signaling <t>in</t> <t>macrophages</t> to tumor and Sertoli cells. ( G ) Feature plots of <t>APP-CD74</t> by ST in Patient 3 and Patient 4. ( H ) Feature plots of MDK-NCL by ST in Patient 3 and Patient 4. ( I ) Mapped SPP and MK signaling pathways in ST, colored by Seurat clusters. ( J ) Violin plots showing the expression level of APP-CD74 genes across the cell types in the leading edge and the tumor core, respectively. The y-axis shows the normalized read count. ( K ) Representative immunofluorescence images showing expression of CTNNB1 and CD74 (n = 4). Nuclei were stained with DAPI. ( L ) Relative mRNA expression of MRC1 and ARG1 (M2-type macrophage markers) and IL1B (M1-type macrophage marker) in macrophages treated with APP. ( M ) Relative mRNA expression of MMP2 (a marker associated with phagocytic function in macrophages) in macrophages treated with APP. The P value was calculated by Welch’s t-test. *P < 0.05, **P < 0.01, ***P < 0.001
Rabbit Monoclonal Anti Aβ 6e10 Antibody, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cell signaling technology 2452  (Cell Signaling Technology Inc)
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Disordered cellular communication in TSCST. ( A ) Bar plot showing the number of inferred interactions in the leading edge and the tumor core. ( B ) Bar plot showing the interaction strength in the leading edge and the tumor core. ( C ) Circle plots display ligand-receptor interaction weights between distinct cellular components in the leading edge and the tumor core. Colors distinguish cell types. The circle size is proportional to the number of cells in each cluster, and the edge width represents communication probability. ( D ) Dot plots show the increased ligand-receptor interactions on the leading edge. ( E ) Dot plots showing the increased ligand-receptor interactions in the tumor core. ( F ) Dot plots show increased signaling <t>in</t> <t>macrophages</t> to tumor and Sertoli cells. ( G ) Feature plots of <t>APP-CD74</t> by ST in Patient 3 and Patient 4. ( H ) Feature plots of MDK-NCL by ST in Patient 3 and Patient 4. ( I ) Mapped SPP and MK signaling pathways in ST, colored by Seurat clusters. ( J ) Violin plots showing the expression level of APP-CD74 genes across the cell types in the leading edge and the tumor core, respectively. The y-axis shows the normalized read count. ( K ) Representative immunofluorescence images showing expression of CTNNB1 and CD74 (n = 4). Nuclei were stained with DAPI. ( L ) Relative mRNA expression of MRC1 and ARG1 (M2-type macrophage markers) and IL1B (M1-type macrophage marker) in macrophages treated with APP. ( M ) Relative mRNA expression of MMP2 (a marker associated with phagocytic function in macrophages) in macrophages treated with APP. The P value was calculated by Welch’s t-test. *P < 0.05, **P < 0.01, ***P < 0.001
Cell Signaling Technology 2452, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human recombinant app protein  (MedChemExpress)
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MedChemExpress human recombinant app protein
Disordered cellular communication in TSCST. ( A ) Bar plot showing the number of inferred interactions in the leading edge and the tumor core. ( B ) Bar plot showing the interaction strength in the leading edge and the tumor core. ( C ) Circle plots display ligand-receptor interaction weights between distinct cellular components in the leading edge and the tumor core. Colors distinguish cell types. The circle size is proportional to the number of cells in each cluster, and the edge width represents communication probability. ( D ) Dot plots show the increased ligand-receptor interactions on the leading edge. ( E ) Dot plots showing the increased ligand-receptor interactions in the tumor core. ( F ) Dot plots show increased signaling <t>in</t> <t>macrophages</t> to tumor and Sertoli cells. ( G ) Feature plots of <t>APP-CD74</t> by ST in Patient 3 and Patient 4. ( H ) Feature plots of MDK-NCL by ST in Patient 3 and Patient 4. ( I ) Mapped SPP and MK signaling pathways in ST, colored by Seurat clusters. ( J ) Violin plots showing the expression level of APP-CD74 genes across the cell types in the leading edge and the tumor core, respectively. The y-axis shows the normalized read count. ( K ) Representative immunofluorescence images showing expression of CTNNB1 and CD74 (n = 4). Nuclei were stained with DAPI. ( L ) Relative mRNA expression of MRC1 and ARG1 (M2-type macrophage markers) and IL1B (M1-type macrophage marker) in macrophages treated with APP. ( M ) Relative mRNA expression of MMP2 (a marker associated with phagocytic function in macrophages) in macrophages treated with APP. The P value was calculated by Welch’s t-test. *P < 0.05, **P < 0.01, ***P < 0.001
Human Recombinant App Protein, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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antibodies for app  (MedChemExpress)
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MedChemExpress antibodies for app
Disordered cellular communication in TSCST. ( A ) Bar plot showing the number of inferred interactions in the leading edge and the tumor core. ( B ) Bar plot showing the interaction strength in the leading edge and the tumor core. ( C ) Circle plots display ligand-receptor interaction weights between distinct cellular components in the leading edge and the tumor core. Colors distinguish cell types. The circle size is proportional to the number of cells in each cluster, and the edge width represents communication probability. ( D ) Dot plots show the increased ligand-receptor interactions on the leading edge. ( E ) Dot plots showing the increased ligand-receptor interactions in the tumor core. ( F ) Dot plots show increased signaling <t>in</t> <t>macrophages</t> to tumor and Sertoli cells. ( G ) Feature plots of <t>APP-CD74</t> by ST in Patient 3 and Patient 4. ( H ) Feature plots of MDK-NCL by ST in Patient 3 and Patient 4. ( I ) Mapped SPP and MK signaling pathways in ST, colored by Seurat clusters. ( J ) Violin plots showing the expression level of APP-CD74 genes across the cell types in the leading edge and the tumor core, respectively. The y-axis shows the normalized read count. ( K ) Representative immunofluorescence images showing expression of CTNNB1 and CD74 (n = 4). Nuclei were stained with DAPI. ( L ) Relative mRNA expression of MRC1 and ARG1 (M2-type macrophage markers) and IL1B (M1-type macrophage marker) in macrophages treated with APP. ( M ) Relative mRNA expression of MMP2 (a marker associated with phagocytic function in macrophages) in macrophages treated with APP. The P value was calculated by Welch’s t-test. *P < 0.05, **P < 0.01, ***P < 0.001
Antibodies For App, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Disordered cellular communication in TSCST. ( A ) Bar plot showing the number of inferred interactions in the leading edge and the tumor core. ( B ) Bar plot showing the interaction strength in the leading edge and the tumor core. ( C ) Circle plots display ligand-receptor interaction weights between distinct cellular components in the leading edge and the tumor core. Colors distinguish cell types. The circle size is proportional to the number of cells in each cluster, and the edge width represents communication probability. ( D ) Dot plots show the increased ligand-receptor interactions on the leading edge. ( E ) Dot plots showing the increased ligand-receptor interactions in the tumor core. ( F ) Dot plots show increased signaling in macrophages to tumor and Sertoli cells. ( G ) Feature plots of APP-CD74 by ST in Patient 3 and Patient 4. ( H ) Feature plots of MDK-NCL by ST in Patient 3 and Patient 4. ( I ) Mapped SPP and MK signaling pathways in ST, colored by Seurat clusters. ( J ) Violin plots showing the expression level of APP-CD74 genes across the cell types in the leading edge and the tumor core, respectively. The y-axis shows the normalized read count. ( K ) Representative immunofluorescence images showing expression of CTNNB1 and CD74 (n = 4). Nuclei were stained with DAPI. ( L ) Relative mRNA expression of MRC1 and ARG1 (M2-type macrophage markers) and IL1B (M1-type macrophage marker) in macrophages treated with APP. ( M ) Relative mRNA expression of MMP2 (a marker associated with phagocytic function in macrophages) in macrophages treated with APP. The P value was calculated by Welch’s t-test. *P < 0.05, **P < 0.01, ***P < 0.001

Journal: Biomarker Research

Article Title: Single-cell and spatial transcriptome analysis reveals the potential therapeutic targets for testicular sex cord-stromal cell tumor

doi: 10.1186/s40364-026-00924-0

Figure Lengend Snippet: Disordered cellular communication in TSCST. ( A ) Bar plot showing the number of inferred interactions in the leading edge and the tumor core. ( B ) Bar plot showing the interaction strength in the leading edge and the tumor core. ( C ) Circle plots display ligand-receptor interaction weights between distinct cellular components in the leading edge and the tumor core. Colors distinguish cell types. The circle size is proportional to the number of cells in each cluster, and the edge width represents communication probability. ( D ) Dot plots show the increased ligand-receptor interactions on the leading edge. ( E ) Dot plots showing the increased ligand-receptor interactions in the tumor core. ( F ) Dot plots show increased signaling in macrophages to tumor and Sertoli cells. ( G ) Feature plots of APP-CD74 by ST in Patient 3 and Patient 4. ( H ) Feature plots of MDK-NCL by ST in Patient 3 and Patient 4. ( I ) Mapped SPP and MK signaling pathways in ST, colored by Seurat clusters. ( J ) Violin plots showing the expression level of APP-CD74 genes across the cell types in the leading edge and the tumor core, respectively. The y-axis shows the normalized read count. ( K ) Representative immunofluorescence images showing expression of CTNNB1 and CD74 (n = 4). Nuclei were stained with DAPI. ( L ) Relative mRNA expression of MRC1 and ARG1 (M2-type macrophage markers) and IL1B (M1-type macrophage marker) in macrophages treated with APP. ( M ) Relative mRNA expression of MMP2 (a marker associated with phagocytic function in macrophages) in macrophages treated with APP. The P value was calculated by Welch’s t-test. *P < 0.05, **P < 0.01, ***P < 0.001

Article Snippet: THP-1-induced macrophages treated with APP protein (MedChemExpress, Shanghai, Catalogue number: HY- P72834 ) were collected, and total RNA was extracted using TRIzol Reagent (Invitrogen, 15596018CN, USA).

Techniques: Protein-Protein interactions, Expressing, Immunofluorescence, Staining, Marker